Top 100 Most Cited

The 100 most-cited inflammatory bowel disease papers of all time, ranked by OpenAlex citation count.

Ranked from the IBDology fleet corpus — all IBD-surgery collections.
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1Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.
Ng · 2017 · Lancet
4,850
2Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Jostins · 2012 · Nature
3,772
3Ulcerative colitis.
Ungaro · 2017 · Lancet
2,933
4Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.
Silverberg MS · 2005 · Can J Gastroenterol
2,706
5Inflammatory bowel disease.
Abraham · 2009 · N Engl J Med
2,295
6Infliximab for the treatment of fistulas in patients with Crohn's disease.
Present DH · 1999 · N Engl J Med
2,140
7The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy.
Dougados · 1991 · Arthritis Rheum
1,928
8British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.
Lamb · 2019 · Gut
1,855
9IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.
Grivennikov S · 2009 · Cancer Cell
1,833
10Ulcerative colitis
Ordás · 2012 · Lancet
1,764
11Infliximab maintenance therapy for fistulizing Crohn's disease.
Sands BE · 2004 · N Engl J Med
1,723
12Epidemiology and natural history of inflammatory bowel diseases.
Cosnes · 2011 · Gastroenterology
1,669
13Crohn's disease.
Baumgart · 2012 · Lancet
1,636
14Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.
Riddell · 1983 · Hum Pathol
1,595
153rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: Part 1: Diagnosis and Medical Management.
Gomollón F · 2017 · J Crohns Colitis
1,579
16TNF-mediated inflammatory disease.
Bradley · 2008 · J Pathol
1,540
17Predictability of the postoperative course of Crohn's disease.
Rutgeerts P · 1990 · Gastroenterology
1,465
18Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders
Magro · 2017 · J Crohns Colitis
1,458
19Inflammatory bowel disease: clinical aspects and established and evolving therapies
Baumgart · 2007 · Lancet
1,447
20Ulcerative colitis and colorectal cancer. A population-based study.
Ekbom · 1990 · N Engl J Med
1,444
21Cyclosporine in severe ulcerative colitis refractory to steroid therapy.
Lichtiger · 1994 · N Engl J Med
1,439
22Microbial influences in inflammatory bowel diseases
Sartor · 2008 · Gastroenterology
1,433
23Ulcerative colitis
Kobayashi · 2020 · Nat Rev Dis Primers
1,391
24Therapeutic roles of curcumin: lessons learned from clinical trials.
Gupta · 2013 · AAPS J
1,287
25Ulcerative colitis.
Le Berre Catherine · 2023 · Lancet
1,280
26The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general.
Rudwaleit · 2011 · Ann Rheum Dis
1,249
27Tumor necrosis factor antagonist mechanisms of action: a comprehensive review.
Tracey · 2008 · Pharmacol Ther
1,234
28ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents.
Levine A · 2014 · J Pediatr Gastroenterol Nutr
1,124
29The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management.
Dignass · 2010 · J Crohns Colitis
1,107
30ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment.
Torres J · 2020 · J Crohns Colitis
1,106
31Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Anderson CA · 2011 · Nat Genet
1,079
32The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients.
Greenstein · 1976 · Medicine (Baltimore)
1,063
33Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters Committee
Kornbluth · 2010 · Am J Gastroenterol
1,044
34Proctocolectomy without ileostomy for ulcerative colitis.
Parks A · 1978 · Br Med J
1,030
35Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation.
Itzkowitz SH · 2004 · Am J Physiol Gastrointest Liver Physiol
1,024
36Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial
Gionchetti · 2000 · Gastroenterology
1,022
37Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis.
Rutter · 2004 · Gastroenterology
980
38Development and validation of a pediatric Crohn's disease activity index.
Hyams · 1991 · J Pediatr Gastroenterol Nutr
965
39Ileal pouch-anal anastomoses complications and function in 1005 patients
Fazio · 1995 · Ann Surg
961
40A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998.
Gasche · 2000 · Inflamm Bowel Dis
957
41Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management.
Harbord · 2017 · J Crohns Colitis
942
42Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases.
Shi Y · 2018 · Nat Rev Nephrol
941
43Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort.
Frøslie · 2007 · Gastroenterology
938
44Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.
Buonocore · 2010 · Nature
924
45Intestinal inflammation and cancer.
Ullman TA · 2011 · Gastroenterology
920
46Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study.
Beaugerie L · 2009 · Lancet
895
47The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.
Taurog · 1994 · J Exp Med
889
48Diagnosis and management of primary sclerosing cholangitis.
Chapman · 2010 · Hepatology
880
49The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis.
Van Assche · 2010 · J Crohns Colitis
857
50Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research.
Jurenka · 2009 · Altern Med Rev
839
51Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study.
Järnerot · 2005 · Gastroenterology
836
52The natural history of adult Crohn's disease in population-based cohorts.
Peyrin-Biroulet L · 2010 · Am J Gastroenterol
832
53Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial.
Panés J · 2016 · Lancet
828
54Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease.
Ruemmele FM · 2014 · J Crohns Colitis
819
55European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa.
Zouboulis · 2015 · J Eur Acad Dermatol Venereol
812
56Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis.
Baeten · 2015 · N Engl J Med
811
57ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update.
Ramiro · 2023 · Ann Rheum Dis
811
58The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota.
Schwartz DA · 2002 · Gastroenterology
810
59CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease.
Lesage · 2002 · Am J Hum Genet
796
60Guidelines for the management of inflammatory bowel disease in adults.
Carter · 2004 · Gut
793
61Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
Akdis · 2021 · Nat Rev Immunol
782
62Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis.
Colombel · 2011 · Gastroenterology
770
63Reduced Paneth cell alpha-defensins in ileal Crohn's disease
Wehkamp · 2005 · Proc Natl Acad Sci U S A
769
64Probiotic bacteria enhance murine and human intestinal epithelial barrier function.
Madsen · 2001 · Gastroenterology
764
65Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.
Popivanova BK · 2008 · J Clin Invest
759
66Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics
Sartor · 2004 · Gastroenterology
759
67Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
Gionchetti · 2003 · Gastroenterology
751
68CARD15 mutations in Blau syndrome.
Miceli-Richard · 2001 · Nat Genet
750
69Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease.
Van Limbergen J · 2008 · Gastroenterology
746
70Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology.
Chapman RW · 1980 · Gut
741
71Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies.
Jess · 2012 · Clin Gastroenterol Hepatol
737
72Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management
Dignass · 2012 · J Crohns Colitis
736
73Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection.
Endo · 2008 · Ann Surg
727
74Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry.
Lichtenstein GR · 2006 · Clin Gastroenterol Hepatol
721
75Predictors of Crohn's disease.
Beaugerie L · 2006 · Gastroenterology
720
76Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer.
Zhang M · 2016 · Biomaterials
718
77Risk of surgery for inflammatory bowel diseases has decreased over time: a systematic review and meta-analysis of population-based studies.
Frolkis · 2013 · Gastroenterology
716
78Risk factors for cholangiocarcinoma.
Tyson · 2011 · Hepatology
716
79Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.
2013 · Nat Genet
711
80Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease.
Darfeuille-Michaud A · 1998 · Gastroenterology
693
81Colorectal Cancer in Inflammatory Bowel Disease: Mechanisms and Management.
Shah SC · 2022 · Gastroenterology
685
82Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum.
D'Haens · 1998 · Gastroenterology
684
83Primary sclerosing cholangitis - a comprehensive review.
Karlsen · 2017 · J Hepatol
684
84Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation
Sinha · 2020 · Cell Host Microbe
681
85Management of Crohn's disease in adults.
Lichtenstein GR · 2009 · Am J Gastroenterol
680
86Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler · 2021 · Gastroenterology
675
87Mesenchymal stem cells: mechanisms of inflammation.
Singer NG · 2011 · Annu Rev Pathol
661
88Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study.
Ng SC · 2013 · Gastroenterology
653
89Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis.
Kiesslich R · 2003 · Gastroenterology
650
90Risk factors associated with progression to intestinal complications of Crohn's disease in a population-based cohort.
Thia KT · 2010 · Gastroenterology
641
91Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery.
Rutgeerts P · 1984 · Gut
640
92Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis.
Feldtkeller · 2003 · Rheumatol Int
640
93Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches
Sartor · 2017 · Gastroenterology
640
94Spondyloarthritis.
Dougados · 2011 · Lancet
637
95Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study.
Gupta RB · 2007 · Gastroenterology
629
96Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis.
Cohen · 2007 · Orphanet J Rare Dis
620
97European evidence based consensus for endoscopy in inflammatory bowel disease.
Annese Vito · 2013 · J Crohns Colitis
617
98Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis
Mimura · 2004 · Gut
616
99Predicting outcome in severe ulcerative colitis.
Travis · 1996 · Gut
613
100Behçet's disease. Report of 41 cases and a review of the literature.
Chajek · 1975 · Medicine (Baltimore)
609