Top Cited

The 100 most-cited inflammatory bowel disease papers of all time, ranked by OpenAlex citation count.

Ranked from the IBDology fleet corpus, all IBD-surgery collections.
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1Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.
Ng · 2017 · Lancet
4,781
2Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
2012 · Nature
3,758
3Ulcerative colitis.
Ungaro · 2017 · Lancet
2,898
4Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.
Silverberg MS · 2005 · Can J Gastroenterol
2,706
5Infliximab for the treatment of fistulas in patients with Crohn's disease.
Present DH · 1999 · N Engl J Med
2,135
6The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy.
1991 · Arthritis Rheum
1,922
7British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.
Lamb · 2019 · Gut
1,838
8IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.
Grivennikov S · 2009 · Cancer Cell
1,823
9Ulcerative colitis
Ordás · 2012 · Lancet
1,751
10Infliximab maintenance therapy for fistulizing Crohn's disease.
Sands BE · 2004 · N Engl J Med
1,716
11Epidemiology and natural history of inflammatory bowel diseases.
Cosnes · 2011 · Gastroenterology
1,659
12Crohn's disease.
2012 · Lancet
1,626
13Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.
Riddell · 1983 · Hum Pathol
1,590
143rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: Part 1: Diagnosis and Medical Management.
Gomollón F · 2017 · J Crohns Colitis
1,567
15TNF-mediated inflammatory disease.
2008 · J Pathol
1,528
16Predictability of the postoperative course of Crohn's disease.
Rutgeerts P · 1990 · Gastroenterology
1,460
17Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders
Magro · 2017 · J Crohns Colitis
1,445
18Inflammatory bowel disease: clinical aspects and established and evolving therapies
Baumgart · 2007 · Lancet
1,444
19Ulcerative colitis and colorectal cancer. A population-based study.
Ekbom · 1990 · N Engl J Med
1,440
20Cyclosporine in severe ulcerative colitis refractory to steroid therapy.
Lichtiger · 1994 · N Engl J Med
1,435
21Microbial influences in inflammatory bowel diseases
Sartor · 2008 · Gastroenterology
1,431
22Ulcerative colitis
Kobayashi · 2020 · Nat Rev Dis Primers
1,351
23Therapeutic roles of curcumin: lessons learned from clinical trials.
2013 · AAPS J
1,278
24The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general.
2011 · Ann Rheum Dis
1,236
25Tumor necrosis factor antagonist mechanisms of action: a comprehensive review.
2008 · Pharmacol Ther
1,230
26Ulcerative colitis.
Le Berre Catherine · 2023 · Lancet
1,219
27ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents.
Levine A · 2014 · J Pediatr Gastroenterol Nutr
1,109
28The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management.
2010 · J Crohns Colitis
1,107
29ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment.
Torres J · 2020 · J Crohns Colitis
1,097
30Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Anderson CA · 2011 · Nat Genet
1,079
31The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients.
Greenstein · 1976 · Medicine (Baltimore)
1,063
32Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters Committee
Kornbluth · 2010 · Am J Gastroenterol
1,043
33Proctocolectomy without ileostomy for ulcerative colitis.
Parks A · 1978 · Br Med J
1,028
34Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial
Gionchetti · 2000 · Gastroenterology
1,021
35Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation.
Itzkowitz SH · 2004 · Am J Physiol Gastrointest Liver Physiol
1,020
36Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis.
2004 · Gastroenterology
975
37Development and validation of a pediatric Crohn's disease activity index.
1991 · J Pediatr Gastroenterol Nutr
964
38Ileal pouch-anal anastomoses complications and function in 1005 patients
Fazio · 1995 · Ann Surg
959
39A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998.
2000 · Inflamm Bowel Dis
957
40Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort.
Frøslie · 2007 · Gastroenterology
938
41Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases.
Shi Y · 2018 · Nat Rev Nephrol
930
42Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.
2010 · Nature
924
43Intestinal inflammation and cancer.
Ullman TA · 2011 · Gastroenterology
915
44Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study.
Beaugerie L · 2009 · Lancet
895
45Diagnosis and management of primary sclerosing cholangitis.
2010 · Hepatology
875
46The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis.
2010 · J Crohns Colitis
857
47Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research.
2009 · Altern Med Rev
836
48Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study.
Järnerot · 2005 · Gastroenterology
833
49The natural history of adult Crohn's disease in population-based cohorts.
Peyrin-Biroulet L · 2010 · Am J Gastroenterol
831
50Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial.
Panés J · 2016 · Lancet
821
51Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease.
Ruemmele FM · 2014 · J Crohns Colitis
815
52Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis.
2015 · N Engl J Med
807
53European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa.
2015 · J Eur Acad Dermatol Venereol
807
54The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota.
Schwartz DA · 2002 · Gastroenterology
801
55CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease.
2002 · Am J Hum Genet
795
56Guidelines for the management of inflammatory bowel disease in adults.
Carter · 2004 · Gut
786
57ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update.
2023 · Ann Rheum Dis
786
58Reduced Paneth cell alpha-defensins in ileal Crohn's disease
Wehkamp · 2005 · Proc Natl Acad Sci U S A
768
59Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis.
Colombel · 2011 · Gastroenterology
768
60Probiotic bacteria enhance murine and human intestinal epithelial barrier function.
Madsen · 2001 · Gastroenterology
763
61Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics
Sartor · 2004 · Gastroenterology
758
62Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.
Popivanova BK · 2008 · J Clin Invest
756
63Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
2021 · Nat Rev Immunol
756
64Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
Gionchetti · 2003 · Gastroenterology
749
65CARD15 mutations in Blau syndrome.
2001 · Nat Genet
748
66Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease.
Van Limbergen J · 2008 · Gastroenterology
744
67Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology.
Chapman RW · 1980 · Gut
740
68Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management
Dignass · 2012 · J Crohns Colitis
735
69Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies.
Jess · 2012 · Clin Gastroenterol Hepatol
731
70Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry.
Lichtenstein GR · 2006 · Clin Gastroenterol Hepatol
720
71Risk factors for cholangiocarcinoma.
2011 · Hepatology
715
72Predictors of Crohn's disease.
Beaugerie L · 2006 · Gastroenterology
714
73Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer.
Zhang M · 2016 · Biomaterials
700
74Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum.
D'Haens · 1998 · Gastroenterology
682
75Management of Crohn's disease in adults.
Lichtenstein GR · 2009 · Am J Gastroenterol
679
76Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation
Sinha · 2020 · Cell Host Microbe
671
77Primary sclerosing cholangitis - a comprehensive review.
2017 · J Hepatol
670
78Mesenchymal stem cells: mechanisms of inflammation.
Singer NG · 2011 · Annu Rev Pathol
661
79Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
2021 · Gastroenterology
659
80Colorectal Cancer in Inflammatory Bowel Disease: Mechanisms and Management.
Shah SC · 2022 · Gastroenterology
656
81Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study.
Ng SC · 2013 · Gastroenterology
650
82Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis.
Kiesslich R · 2003 · Gastroenterology
650
83Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery.
Rutgeerts P · 1984 · Gut
639
84Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis.
2003 · Rheumatol Int
639
85Risk factors associated with progression to intestinal complications of Crohn's disease in a population-based cohort.
Thia KT · 2010 · Gastroenterology
639
86Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches
Sartor · 2017 · Gastroenterology
635
87Spondyloarthritis.
2011 · Lancet
632
88Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study.
Gupta RB · 2007 · Gastroenterology
624
89European evidence based consensus for endoscopy in inflammatory bowel disease.
Annese Vito · 2013 · J Crohns Colitis
616
90Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis
Mimura · 2004 · Gut
613
91Behçet's disease. Report of 41 cases and a review of the literature.
1975 · Medicine (Baltimore)
609
92Predicting outcome in severe ulcerative colitis.
Travis · 1996 · Gut
606
93Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum.
Rutgeerts · 1991 · Lancet
598
94Clinical course during the first 10 years of ulcerative colitis: results from a population-based inception cohort (IBSEN Study).
Solberg · 2009 · Scand J Gastroenterol
597
95Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection.
Rutgeerts P · 1995 · Gastroenterology
596
96A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation.
García-Olmo D · 2005 · Dis Colon Rectum
587
97Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
2016 · Nat Genet
585
98Pouchitis after ileal pouch-anal anastomosis: a Pouchitis Disease Activity Index
Sandborn · 1994 · Mayo Clin Proc
585
99Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline.
2015 · Endoscopy
582
100Inflammatory Bowel Disease in Children and Adolescents.
2015 · JAMA Pediatr
581