Top 100 Most Disruptive

The 100 most-disruptive inflammatory bowel disease papers of all time, ranked by the CD₅ disruption index over the NIH iCite citation graph.

Curated by · Professor of Surgery, Department of Colon & Rectal Surgery, Cleveland Clinic · Corpus last refreshed · Publications

Ranked from the IBDology fleet corpus — all IBD-surgery collections.
#PaperAltmetricCD index
1Post-surgical pyoderma gangrenosum of the vaginal vault associated with ulcerative colitis and Behçet's disease; a case report.
Lilford · 1989 · Eur J Obstet Gynecol Reprod Biol
+0.960
24 cites
2Long-term survival between total colectomy versus proctocolectomy in patients with FAP: a registry-based, observational cohort study
Ardoino · 2020 · Tumori
+0.818
20 cites
3Campylobacter colitis associated with erythema nodosum.
Ellis · 1982 · Br Med J (Clin Res Ed)
+0.763
29 cites
4Minimal surgery for chronic obstruction in patients with extensive or universal Crohn's disease.
Lee EC · 1982 · Ann R Coll Surg Engl
+0.760
214 cites
5Surgical treatment of toxic megacolon. Ileostomy and colostomy to prepare patients for colectomy.
Turnbull · 1971 · Am J Surg
+0.730
121 cites
6Total colectomy and ileorectal anastomosis in diffuse ulcerative colitis.
AYLETT · 1957 · Br Med J
+0.703
34 cites
7Chronic ulcerative colitis associated with malignant disease. 1928.
Bargen JA · 1994 · Dis Colon Rectum
+0.690
20 cites
8Three hundred cases of diffuse ulcerative colitis treated by total colectomy and ileo-rectal anastomosis.
Aylett · 1966 · Br Med J
+0.636
137 cites
9Intra-abdominal "reservoir" in patients with permanent ileostomy. Preliminary observations on a procedure resulting in fecal "continence" in five ileostomy patients.
Kock · 1969 · Arch Surg
+0.589
476 cites
10ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents.
Levine A · 2014 · J Pediatr Gastroenterol Nutr
+0.557
1,124 cites
11AGA Clinical Practice Update on Surveillance for Hepatobiliary Cancers in Patients With Primary Sclerosing Cholangitis: Expert Review.
Bowlus · 2019 · Clin Gastroenterol Hepatol
+0.550
81 cites
12Laparoscopic total proctocolectomy with creation of ileostomy for ulcerative colitis: report of two cases.
Peters · 1992 · J Laparoendosc Surg
+0.496
63 cites
13Ulcerative colitis treated by total colectomy and ileorectal anastomosis: a ten-year review.
AYLETT · 1963 · Proc R Soc Med
+0.424
39 cites
14Ankylosing spondylitis in a Canadian Indian population.
Gofton · 1966 · Ann Rheum Dis
+0.418
41 cites
15Predicting Outcomes in Pediatric Crohn's Disease for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease-Ahead Program.
Ricciuto A · 2021 · Gastroenterology
+0.418
78 cites
16Proctocolectomy without ileostomy for ulcerative colitis.
Parks A · 1978 · Br Med J
+0.400
1,030 cites
17Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis
Burke · 2020 · N Engl J Med
+0.371
61 cites
18Ulcerative colitis with relative sparing of the rectum. Clinical features, histology, and prognosis.
Spiliadis · 1987 · Dis Colon Rectum
+0.356
48 cites
19American Gastroenterological Association medical position statement: perianal Crohn's disease.
American Gastroenterological Association Clinical Practice Committee · 2003 · Gastroenterology
+0.325
134 cites
20Ileostomy for ulcerative colitis; technique, complications, and management.
WARREN · 1951 · Surg Gynecol Obstet
+0.314
136 cites
21An analysis of 10218 ulcerative colitis cases in China.
Jiang XL · 2002 · World J Gastroenterol
+0.296
135 cites
22Treatment of haemorrhoids in patients with inflammatory bowel disease.
Jeffery PJ · 1977 · Lancet
+0.295
70 cites
23Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease.
Hellers · 1980 · Gut
+0.292
365 cites
24Surgical treatment of ulcerative colitis.
CATTELL · 1948 · JAMA
+0.283
33 cites
25Life expectancy after colectomy and ileorectal anastomosis for familial adenomatous polyposis.
Nugent · 1993 · Dis Colon Rectum
+0.270
149 cites
26SQUAMOUS CELL CARCINOMA OF THE RECTUM COMPLICATING ULCERATIVE COLITIS: REPORT OF TWO CASES.
HOHM · 1964 · Mayo Clin Proc
+0.250
36 cites
27Extended use of sodium tetradecyl sulfate in treatment of hemangiomas and other related conditions
Woods · 1987 · Plast Reconstr Surg
+0.226
39 cites
28Results of a survey to evaluate whether vaginal delivery and episiotomy lead to perineal involvement in women with Crohn's disease.
Brandt LJ · 1995 · Am J Gastroenterol
+0.225
74 cites
29An Update on the Medical Management of Inflammatory Pouch Complications
Quinn · 2020 · Am J Gastroenterol
+0.221
31 cites
30Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease-Ahead Program.
Orlanski-Meyer · 2021 · Gastroenterology
+0.218
52 cites
31Omeprazole for duodenal ulceration in Crohn's disease.
Valori · 1990 · BMJ
+0.215
29 cites
32["Strictureplasty" in Crohn disease].
Alexander-Williams J · 1982 · Chirurg
+0.212
23 cites
33Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy.
Blackstone · 1981 · Gastroenterology
+0.207
413 cites
34The relative significance of preoperative oral antibiotics, mechanical bowel preparation, and preoperative peritoneal contamination in the avoidance of sepsis after radical surgery for ulcerative colitis and Crohn's disease of the large bowel.
Barker · 1971 · Br J Surg
+0.205
58 cites
35Effects of Primary Sclerosing Cholangitis on Risks of Cancer and Death in People With Inflammatory Bowel Disease, Based on Sex, Race, and Age.
Trivedi · 2020 · Gastroenterology
+0.198
154 cites
36Primary resection of the colon in acute ulcerative colitis.
RIPSTEIN · 1953 · JAMA
+0.188
21 cites
37The role of colonoscopy in the differential diagnosis of inflammatory bowel disease.
Waye JD · 1977 · Gastrointest Endosc
+0.185
74 cites
38Prevalence of primary sclerosing cholangitis in patients with ulcerative colitis.
Olsson · 1991 · Gastroenterology
+0.175
311 cites
39Diagnostic value of double balloon enteroscopy for small-intestinal disease: experience from China.
Zhi · 2007 · Gastrointest Endosc
+0.170
26 cites
40OCULAR COMPLICATIONS OF ULCERATIVE COLITIS.
ELLIS · 1964 · Am J Ophthalmol
+0.166
39 cites
41Treatment of colorectal and ileoanal anastomotic sinuses
Whitlow · 1997 · Dis Colon Rectum
+0.166
55 cites
42Comparison of handsewn with stapled loop ileostomy closures
Hull · 1996 · Dis Colon Rectum
+0.161
58 cites
43Risk factors for recurrence of primary sclerosing cholangitis of liver allograft.
Vera · 2002 · Lancet
+0.156
163 cites
44Hyperalimentation as primary therapy for inflammatory bowel disease.
Fischer · 1973 · Am J Surg
+0.154
153 cites
45A roentgenologic sign of regional enteritis of the duodenum.
Legge · 1971 · Radiology
+0.153
21 cites
46The role of microRNA-16 in the pathogenesis of autoimmune diseases: A comprehensive review.
Yan · 2019 · Biomed Pharmacother
+0.150
48 cites
47Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery.
Rutgeerts P · 1984 · Gut
+0.144
640 cites
48Course of ulcerative colitis: analysis of changes in disease activity over years.
Langholz · 1994 · Gastroenterology
+0.142
528 cites
49The effects of diversion of intestinal contents on the progress of Crohn's disease of the large bowel.
Burman JH · 1971 · Gut
+0.141
93 cites
50Geographical variation in disease presentation. Does it constitute a problem and can information science help?
de Dombal · 1981 · Med Decis Making
+0.138
26 cites
51High serum tumor necrosis factor-alpha levels are associated with lack of response to infliximab in fistulizing Crohn's disease.
Martínez-Borra J · 2002 · Am J Gastroenterol
+0.138
93 cites
52Repair of persistent perineal sinuses by means of a pedicle flap of musculus gracilis. Case report.
Bartholdson · 1975 · Scand J Plast Reconstr Surg
+0.135
41 cites
53Toxic megacolon.
Ripstein · 1973 · Dis Colon Rectum
+0.135
20 cites
54Pouch advancement and neoileoanal anastomosis for anastomotic stricture and anovaginal fistula complicating restorative proctocolectomy
Fazio · 1992 · Br J Surg
+0.134
60 cites
55Surgical measures as supplements to the management of idiopathic ulcerative colitis; cancer, cirrhosis, and arthritis as frequent complications.
DENNIS · 1952 · Surgery
+0.133
84 cites
56The treatment of acute toxic ulcerative colitis by ileostomy and simultaneous colectomy.
CRILE · 1951 · Gastroenterology
+0.130
50 cites
57Predictability of the postoperative course of Crohn's disease.
Rutgeerts P · 1990 · Gastroenterology
+0.129
1,465 cites
58Emerging role of IL-35 in inflammatory autoimmune diseases.
Su · 2018 · Autoimmun Rev
+0.129
78 cites
59Prospective, randomized trial comparing laparoscopic vs. conventional surgery for refractory ileocolic Crohn's disease.
Milsom · 2001 · Dis Colon Rectum
+0.127
249 cites
60Faecal markers of gastrointestinal inflammation.
Sherwood RA · 2012 · J Clin Pathol
+0.127
47 cites
61Ileorectal anastomosis: review 1952-1968.
Aylett · 1971 · Proc R Soc Med
+0.126
39 cites
62Ocular changes in granulomatous ileocolitis.
Macoul · 1970 · Arch Ophthalmol
+0.126
46 cites
63Quality of life after prophylactic colectomy and ileorectal anastomosis in patients with familial adenomatous polyposis
Church · 1996 · Dis Colon Rectum
+0.124
53 cites
64Paradoxical gastrointestinal effects of interleukin-17 blockers.
Fauny · 2020 · Ann Rheum Dis
+0.123
214 cites
65Fate of the rectal mucosa after rectal mucosectomy and ileoanal anastomosis.
Heppell · 1983 · Dis Colon Rectum
+0.121
105 cites
66Nonspecific granulomatous inflammation of the stomach and duodenum; its relation to regional enteritis.
COMFORT · 1950 · Am J Med Sci
+0.119
98 cites
67Portal bacteraemia in cases of ulcerative colitis submitted to colectomy.
Eade · 1969 · Lancet
+0.118
90 cites
68Endoscopic balloon dilation of colonic and ileo-colonic Crohn's strictures: long-term results.
Breysem Y · 1992 · Gastrointest Endosc
+0.118
93 cites
69An innovative technique for colorectal specimen retrieval: a new era of "natural orifice specimen extraction" (N.O.S.E)
Palanivelu · 2008 · Dis Colon Rectum
+0.117
113 cites
70Pancreatitis as a complication of regional enteritis of the duodenum.
Legge · 1971 · Gastroenterology
+0.116
99 cites
71Symposium. Crohn's disease: anal lesions.
Lockhart-Mummery HE · 1975 · Dis Colon Rectum
+0.116
76 cites
72Effects of orthotopic liver transplantation and immunosuppression on inflammatory bowel disease in primary sclerosing cholangitis patients.
Stephens · 1993 · Transplant Proc
+0.115
49 cites
73Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.
Riddell · 1983 · Hum Pathol
+0.113
1,595 cites
74Cyclosporine in severe ulcerative colitis refractory to steroid therapy.
Lichtiger · 1994 · N Engl J Med
+0.110
1,439 cites
75Serum antibodies to Bacteroides species in chronic inflammatory bowel disease.
Tvede · 1983 · Scand J Gastroenterol
+0.109
42 cites
76THE COURSE AND PROGNOSIS OF ULCERATIVE COLITIS. III. COMPLICATIONS.
EDWARDS · 1964 · Gut
+0.109
464 cites
77Choice of operation for the toxic megacolon phase of nonspecific ulcerative colitis.
Turnbull · 1970 · Surg Clin North Am
+0.106
42 cites
78The fate of ileorectal anastomosis in Crohn's disease.
Burman · 1971 · Gut
+0.104
57 cites
79Crohn's disease of the stomach and duodenum.
Fielding · 1970 · Gut
+0.103
113 cites
80Sclerosing cholangitis after continuous hepatic artery infusion of FUDR.
Kemeny MM · 1985 · Ann Surg
+0.103
136 cites
81AIDS complicated by syphilis can mimic uveitis and Crohn's disease. Case report.
Kleiner · 1987 · Arch Ophthalmol
+0.102
22 cites
82Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology.
Chapman RW · 1980 · Gut
+0.102
741 cites
83Subtotal colectomy for ulcerative colitis: complications related to the rectal remnant.
Carter F · 1991 · Dis Colon Rectum
+0.101
76 cites
84Influence on sexual function of abdominoperineal resection for ulcerative colitis.
STAHLGREN · 1958 · N Engl J Med
+0.100
40 cites
85Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis.
Feldtkeller · 2003 · Rheumatol Int
+0.099
640 cites
86The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients.
Greenstein · 1976 · Medicine (Baltimore)
+0.099
1,063 cites
87Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos).
Kiriyama S · 2018 · J Hepatobiliary Pancreat Sci
+0.097
555 cites
88Social prognosis in patients with ulcerative colitis.
Hendriksen · 1980 · Br Med J
+0.097
51 cites
89Anal complications in Crohn's disease.
Williams DR · 1981 · Dis Colon Rectum
+0.095
156 cites
90Single-patient randomised clinical trial. Use in determining optimum treatment for patient with inflammation of Kock continent ileostomy reservoir
McLeod · 1986 · Lancet
+0.093
68 cites
91Primary closure of perineal wound after proctocolectomy or rectal excision.
Hultén · 1971 · Acta Chir Scand
+0.093
36 cites
92The Pathogenesis of Extraintestinal Manifestations: Implications for IBD Research, Diagnosis, and Therapy.
Hedin · 2019 · J Crohns Colitis
+0.092
174 cites
93Laparoscopically assisted ileocolectomy in Crohn's disease.
Milsom · 1993 · Surg Laparosc Endosc
+0.091
77 cites
94Gastric acid secretion in Crohn's disease in relation to disease activity and bowel resection.
Fielding · 1971 · Lancet
+0.090
29 cites
95Active ulcerative colitis associated with low prevalence of Blastocystis and Dientamoeba fragilis infection.
Petersen AM · 2013 · Scand J Gastroenterol
+0.090
83 cites
96Lymphoplasmacytic sclerosing pancreatitis with cholangitis: a variant of primary sclerosing cholangitis extensively involving pancreas.
Kawaguchi · 1991 · Hum Pathol
+0.089
466 cites
97The Prevalence and Incidence of Axial and Peripheral Spondyloarthritis in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Karreman · 2017 · J Crohns Colitis
+0.089
172 cites
98Crohn's disease after gastric bypass surgery for morbid obesity: is there an association?
Ahn · 2005 · Inflamm Bowel Dis
+0.087
40 cites
99Preliminary experience with laparoscopic intestinal surgery for Crohn's disease.
Ludwig · 1996 · Am J Surg
+0.084
99 cites
100The OMGE multinational inflammatory bowel disease survey 1976-1986. A further report on 3175 cases.
Myren J · 1988 · Scand J Gastroenterol Suppl
+0.084
22 cites